Title : The effect of clonidine pretreatment on the perioperative proinflammatory cytokines, cortisol, and ACTH responses in patients undergoing total abdominal hysterectomy.

Pub. Date : 2000 Jun

PMID : 10825337






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1 In the comparison study between the control group and the clonidine group, there was a significant decrease in IL-6 level 3 h after the start of surgery and IL-1beta at preinduction time in the clonidine group, whereas there were no changes in tumor necrosis factor-alpha, cortisol, and ACTH levels. Clonidine interleukin 6 Homo sapiens
2 In the comparison study between the control group and the clonidine group, there was a significant decrease in IL-6 level 3 h after the start of surgery and IL-1beta at preinduction time in the clonidine group, whereas there were no changes in tumor necrosis factor-alpha, cortisol, and ACTH levels. Clonidine interleukin 6 Homo sapiens
3 These results show that clonidine modulates the IL-6 response related to surgical stress. Clonidine interleukin 6 Homo sapiens
4 Clonidine 0.15 mg given as oral premedication resulted in the reduced Interleukin-6 production in response to total abdominal hysterectomy. Clonidine interleukin 6 Homo sapiens