Pub. Date : 2000 May
PMID : 10823262
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Decreased sialic acid content of plasma von Willebrand factor in precapillary pulmonary hypertension. | N-Acetylneuraminic Acid | von Willebrand factor | Homo sapiens |
| 2 | Since asialo vWF has been shown to promote platelet activation and aggregation, we decided to investigate possible changes in the sialic acid content of plasma vWF in patients with precapillary pulmonary hypertension. | N-Acetylneuraminic Acid | von Willebrand factor | Homo sapiens |
| 3 | vWF-associated sialic acid was measured indirectly as a wheat germ agglutinin-reactive substance (WGA-RS, Western blotting), and directly, as a thiobarbituric acid-reactive substance (TBA-RS, spectrophotometric reading). | N-Acetylneuraminic Acid | von Willebrand factor | Homo sapiens |
| 4 | However, patient vWF subunit contained 19% (WGA-RS) to 24% (TBA-RS) less sialic acid than the normal protein (p <0.05 for both determinations). | N-Acetylneuraminic Acid | von Willebrand factor | Homo sapiens |
| 5 | In five patients, vWF-associated sialic acid was below 50% normal. | N-Acetylneuraminic Acid | von Willebrand factor | Homo sapiens |