Title : Novel conformationally constrained tropane analogues by 6-endo-trig radical cyclization and stille coupling - switch of activity toward the serotonin and/or norepinephrine transporter.

Pub. Date : 2000 May 18

PMID : 10821718






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Its p-methoxy analogue 5c is a mixed inhibitor of norepinephrine and serotonin reuptake (K(i) = 187 nM at the NET and 56 nM at the SERT). Norepinephrine solute carrier family 6 member 4 Rattus norvegicus