Title : Fluorescence quenching analysis of the association and dissociation of a diarylheterocycle to cyclooxygenase-1 and cyclooxygenase-2: dynamic basis of cyclooxygenase-2 selectivity.

Pub. Date : 2000 May 23

PMID : 10821698






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) are the enzymes responsible for the biosynthesis of the precursor to the biologically active prostaglandins, prostacyclin, and thromboxane and are the molecular targets for nonsteroidal antiinflammatory drugs (NSAIDs). Epoprostenol prostaglandin-endoperoxide synthase 1 Homo sapiens