Title : Functional expression of P-glycoprotein and multidrug resistance-associated protein (Mrp1) in primary cultures of rat astrocytes.

Pub. Date : 2000 Jun 1

PMID : 10820430






1 Functional Relationships(s)
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1 Our functional analysis of P-gp showed a modest effect of P-gp modulators (CsA, verapamil, PSC 833) on the uptake of colchicine (a substrate of P-gp) by astrocytes, whereas they increased by about 50% the uptake of vincristine (a common substrate of P-gp and MRP) by astrocytes. Cyclosporine ATP binding cassette subfamily C member 2 Rattus norvegicus