Title : Regenerative and proinflammatory effects of thrombin on human proximal tubular cells.

Pub. Date : 2000 Jun

PMID : 10820165






2 Functional Relationships(s)
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1 Interestingly, thrombin-induced DNA synthesis and MCP-1 gene expression were completely blocked by genistein, a specific tyrosine kinase inhibitor, but not by its inactive analogue daidzein, demonstrating a central role for tyrosine kinase activation in the thrombin effects on hPTC. Genistein coagulation factor II, thrombin Homo sapiens
2 Interestingly, thrombin-induced DNA synthesis and MCP-1 gene expression were completely blocked by genistein, a specific tyrosine kinase inhibitor, but not by its inactive analogue daidzein, demonstrating a central role for tyrosine kinase activation in the thrombin effects on hPTC. Genistein coagulation factor II, thrombin Homo sapiens