Title : Substantia nigra glutamate antagonists produce contralateral turning and basal ganglia Fos expression: interactions with D1 and D2 dopamine receptor agonists.

Pub. Date : 2000 Jun 1

PMID : 10819899






3 Functional Relationships(s)
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1 Moreover, intranigral DNQX elicited more turning and greater numbers of Fos-positive striatal neurons in 6-OHDA-lesioned animals than in unlesioned controls, suggesting that the 6-OHDA injection induces functional changes in nigral glutamate transmission. Oxidopamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 Moreover, intranigral DNQX elicited more turning and greater numbers of Fos-positive striatal neurons in 6-OHDA-lesioned animals than in unlesioned controls, suggesting that the 6-OHDA injection induces functional changes in nigral glutamate transmission. Oxidopamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
3 6-OHDA-lesioned rats given 5 microg of intrastriatal quinpirole exhibited both turning and pallidal Fos that was significantly increased by intranigral AP5. Oxidopamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus