Title : Activation of PPARdelta alters lipid metabolism in db/db mice.

Pub. Date : 2000 May 19

PMID : 10818235






2 Functional Relationships(s)
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1 Here we show that treatment of insulin resistant db/db mice with the PPARdelta agonist L-165041, at doses that had no effect on either glucose or triglycerides, raised total plasma cholesterol concentrations. Cholesterol peroxisome proliferator activator receptor delta Mus musculus
2 These data suggest both that PPARdelta is involved in the regulation of cholesterol metabolism in db/db mice and that PPARdelta ligands could potentially have therapeutic value. Cholesterol peroxisome proliferator activator receptor delta Mus musculus