Pub. Date : 2000 May 16
PMID : 10811601
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Angiopoietin-1 inhibits irradiation- and mannitol-induced apoptosis in endothelial cells. | Mannitol | angiopoietin 1 | Homo sapiens |
| 2 | In this study, we examined whether Ang1 prevents apoptosis in endothelial cells treated with irradiation or clinical concentrations of mannitol. | Mannitol | angiopoietin 1 | Homo sapiens |
| 3 | METHODS AND RESULTS: ++Ang1 prevented irradiation- and mannitol-induced apoptosis in human umbilical vein endothelial cells in a dose-dependent manner. | Mannitol | angiopoietin 1 | Homo sapiens |
| 4 | CONCLUSIONS: Ang1 promotes the survival of endothelial cells in irradiation- and mannitol-induced apoptosis through Tie2 receptor binding and PI3-kinase activation. | Mannitol | angiopoietin 1 | Homo sapiens |
| 5 | Pretreatment with Ang1 could be beneficial in maintaining normal endothelial cell integrity during intracoronary irradiation or systemic mannitol therapy. | Mannitol | angiopoietin 1 | Homo sapiens |