PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10811601-0 2000 Angiopoietin-1 inhibits irradiation- and mannitol-induced apoptosis in endothelial cells. Mannitol 41-49 angiopoietin 1 Homo sapiens 0-14 10811601-3 2000 In this study, we examined whether Ang1 prevents apoptosis in endothelial cells treated with irradiation or clinical concentrations of mannitol. Mannitol 135-143 angiopoietin 1 Homo sapiens 35-39 10811601-4 2000 METHODS AND RESULTS: ++Ang1 prevented irradiation- and mannitol-induced apoptosis in human umbilical vein endothelial cells in a dose-dependent manner. Mannitol 55-63 angiopoietin 1 Homo sapiens 23-27 10811601-9 2000 CONCLUSIONS: Ang1 promotes the survival of endothelial cells in irradiation- and mannitol-induced apoptosis through Tie2 receptor binding and PI3-kinase activation. Mannitol 81-89 angiopoietin 1 Homo sapiens 13-17 10811601-10 2000 Pretreatment with Ang1 could be beneficial in maintaining normal endothelial cell integrity during intracoronary irradiation or systemic mannitol therapy. Mannitol 137-145 angiopoietin 1 Homo sapiens 18-22