Title : Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions.

Pub. Date : 2000 Feb-Mar

PMID : 10805063






2 Functional Relationships(s)
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1 It is now commonly agreed that the oxidation of 1,4-dihydropyridine into pyridine, which is one of the main metabolic pathways, is catalysed by the cytochrome P450 (CYP) 3A4 isoform. pyridine cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 It is now commonly agreed that the oxidation of 1,4-dihydropyridine into pyridine, which is one of the main metabolic pathways, is catalysed by the cytochrome P450 (CYP) 3A4 isoform. pyridine cytochrome P450 family 4 subfamily F member 3 Homo sapiens