Title : Bicarbonate enhances the hydroxylation, nitration, and peroxidation reactions catalyzed by copper, zinc superoxide dismutase. Intermediacy of carbonate anion radical.

Pub. Date : 2000 May 12

PMID : 10799477






5 Functional Relationships(s)
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1 The effect of bicarbonate anion (HCO(3)(-)) on the peroxidase activity of copper, zinc superoxide dismutase (SOD1) was investigated using three structurally different probes: 5, 5"-dimethyl-1-pyrroline N-oxide (DMPO), tyrosine, and 2, 2"-azino-bis-[3-ethylbenzothiazoline]-6-sulfonic acid (ABTS). Bicarbonates superoxide dismutase 1 Homo sapiens
2 The effect of bicarbonate anion (HCO(3)(-)) on the peroxidase activity of copper, zinc superoxide dismutase (SOD1) was investigated using three structurally different probes: 5, 5"-dimethyl-1-pyrroline N-oxide (DMPO), tyrosine, and 2, 2"-azino-bis-[3-ethylbenzothiazoline]-6-sulfonic acid (ABTS). Bicarbonates superoxide dismutase 1 Homo sapiens
3 We postulate that HCO(3)(-) enhances SOD1 peroxidase activity via formation of a putative carbonate radical anion. Bicarbonates superoxide dismutase 1 Homo sapiens
4 This new and different perspective on HCO(3)(-)-mediated oxidative reactions of SOD1 may help us understand the free radical mechanism of SOD1 and related mutants linked to amyotrophic lateral sclerosis. Bicarbonates superoxide dismutase 1 Homo sapiens
5 This new and different perspective on HCO(3)(-)-mediated oxidative reactions of SOD1 may help us understand the free radical mechanism of SOD1 and related mutants linked to amyotrophic lateral sclerosis. Bicarbonates superoxide dismutase 1 Homo sapiens