Title : Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.

Pub. Date : 2000 May 4

PMID : 10794694






1 Functional Relationships(s)
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Protein Name
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1 As previously reported, the corresponding linear heptapeptide Ac-Val-His-Ala-Gly-Pro-Ile-Ala-NH(2) (2) binds to hCyp-18 with a low affinity (IC(50) = 850 +/- 220 microM) but a potentially useful selectivity for hCyp-18 relative to hFKBP-12, another abundant PPIase. ala-gly-pro-ile FKBP prolyl isomerase 1A pseudogene 4 Homo sapiens