Title : Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch.

Pub. Date : 2000 Apr

PMID : 10783238






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Cell lines that stably express PS1 Deltaexon 8 or a PS1 protein in which aspartate residue 257 is mutated secrete significant levels of Abeta, whereas Abeta generation is severely reduced in cells transfected with PS1 containing a mutation of aspartate 385. Aspartic Acid amyloid beta precursor protein Homo sapiens
2 Cell lines that stably express PS1 Deltaexon 8 or a PS1 protein in which aspartate residue 257 is mutated secrete significant levels of Abeta, whereas Abeta generation is severely reduced in cells transfected with PS1 containing a mutation of aspartate 385. Aspartic Acid amyloid beta precursor protein Homo sapiens