Pub. Date : 2000 May
PMID : 10779340
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We now show that RanBP1 accumulates in nuclei of cells treated with the export inhibitor, leptomycin B, and collapse of the nucleocytoplasmic Ran:GTP gradient leads to equilibration of RanBP1 across the nuclear envelope. | Guanosine Triphosphate | RAN binding protein 1 | Homo sapiens |
| 2 | We now show that RanBP1 accumulates in nuclei of cells treated with the export inhibitor, leptomycin B, and collapse of the nucleocytoplasmic Ran:GTP gradient leads to equilibration of RanBP1 across the nuclear envelope. | Guanosine Triphosphate | RAN binding protein 1 | Homo sapiens |
| 3 | In permeabilized cells, nuclear accumulation of GST-RanBP1(1-161) requires nuclear Ran:GTP but is not inhibited by a dominant interfering G19V mutant of Ran. | Guanosine Triphosphate | RAN binding protein 1 | Homo sapiens |
| 4 | These data indicate that RanBP1 translocates through the pores by an active, nonclassical mechanism and requires Ran:GTP for nuclear accumulation. | Guanosine Triphosphate | RAN binding protein 1 | Homo sapiens |
| 5 | Shuttling of RanBP1 may function to clear nuclear pores of Ran:GTP, to prevent premature release of import cargo from transport receptors. | Guanosine Triphosphate | RAN binding protein 1 | Homo sapiens |