Pub. Date : 2000 Apr
PMID : 10773741
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Estradiol attenuates the forskolin-induced increase in hypothalamic tyrosine hydroxylase activity. | Colforsin | tyrosine hydroxylase | Rattus norvegicus |
| 2 | The first experiment examined the ability of forskolin to activate TH in the tuberoinfundibular dopaminergic neurons of adult ovariectomized rats with or without estradiol treatment. | Colforsin | tyrosine hydroxylase | Rattus norvegicus |
| 3 | Estradiol treatment reduced both basal and forskolin-stimulated TH activity in the median eminence. | Colforsin | tyrosine hydroxylase | Rattus norvegicus |
| 4 | The second group of experiments examined the effect of estradiol on the forskolin-induced activation of TH in fetal hypothalamic cells cultures. | Colforsin | tyrosine hydroxylase | Rattus norvegicus |
| 5 | Forskolin treatment for 1 h increased TH activity in a concentration-dependent manner in control and estradiol-treated cells, but estradiol attenuated the stimulatory response to 0.01-10 microM forskolin. | Colforsin | tyrosine hydroxylase | Rattus norvegicus |
| 6 | The suppressive effect of estradiol on cAMP-dependent activation of TH was evident with 1-12 h of forskolin treatment. | Colforsin | tyrosine hydroxylase | Rattus norvegicus |
| 7 | Forskolin treatment for 1 h increased radiolabeled phosphate incorporation into TH protein in control but not estradiol-treated cells, suggesting that estradiol interferes with the ability of the cAMP pathway to phosphorylate TH. | Colforsin | tyrosine hydroxylase | Rattus norvegicus |
| 8 | Forskolin treatment for 1 h increased radiolabeled phosphate incorporation into TH protein in control but not estradiol-treated cells, suggesting that estradiol interferes with the ability of the cAMP pathway to phosphorylate TH. | Colforsin | tyrosine hydroxylase | Rattus norvegicus |
| 9 | Forskolin caused a time-dependent increase in TH mRNA signal levels in control cultures. | Colforsin | tyrosine hydroxylase | Rattus norvegicus |
| 10 | The magnitude of the forskolin-induced increase in TH mRNA levels was less in the estradiol-treated cells after 6 h of forskolin treatment, indicating that estradiol hinders cAMP-regulated TH gene expression. | Colforsin | tyrosine hydroxylase | Rattus norvegicus |