Title : Neuronal localization of sterol regulatory element binding protein-1 in the rodent and primate brain: a light and electron microscopic immunocytochemical study.

Pub. Date : 2000

PMID : 10771346






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Since sterol regulatory element binding protein-1 has been shown to be a transcriptional regulator of fatty acid synthesis in vivo, the current findings of a predominantly neuronal nuclear expression of the 68,000 mol. Fatty Acids sterol regulatory element binding transcription factor 1 Mus musculus
2 wt transcriptionally active fragment of sterol regulatory element binding protein-1 highlights the established role of phospholipid metabolites and other fatty-acid containing lipids in neuronal signal transduction and other neuronal functions. Fatty Acids sterol regulatory element binding transcription factor 1 Mus musculus
3 Reduced sterol regulatory element binding protein-1 expression in neurons in Niemann-Pick type C may reflect a deficiency in fatty acid synthesis that could contribute to the neuronal dysfunction in this disorder. Fatty Acids sterol regulatory element binding transcription factor 1 Mus musculus