Title : Involvement of p21Waf1 in mediating inhibition of paclitaxel-induced apoptosis by epidermal growth factor in MDA-MB-468 human breast cancer cells.

Pub. Date : 2000 Jan-Feb

PMID : 10769641






3 Functional Relationships(s)
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1 The induction of apoptosis by paclitaxel was accompanied by an elevated level of p34cdc2 kinase activity, which was inhibited in the presence of EGF during the post-paclitaxel culture period. Paclitaxel cyclin dependent kinase 1 Homo sapiens
2 The induction of apoptosis by paclitaxel was accompanied by an elevated level of p34cdc2 kinase activity, which was inhibited in the presence of EGF during the post-paclitaxel culture period. Paclitaxel cyclin dependent kinase 1 Homo sapiens
3 Incubation of paclitaxel-treated MDA-MB-468 cell extracts with EGF-treated MDA-MB-468 cell extract, which exhibited elevation of p34cdc2 activity, inhibited the kinase activity. Paclitaxel cyclin dependent kinase 1 Homo sapiens