Title : Mimosine is a cell-specific antagonist of folate metabolism.

Pub. Date : 2000 Jun 23

PMID : 10766749






6 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 The effect of mimosine on folate metabolism is associated with decreased cytoplasmic serine hydroxymethyltransferase (cSHMT) expression in MCF-7 cells but not in SH-SY5Y cells. Mimosine serine hydroxymethyltransferase 1 Homo sapiens
2 The effect of mimosine on folate metabolism is associated with decreased cytoplasmic serine hydroxymethyltransferase (cSHMT) expression in MCF-7 cells but not in SH-SY5Y cells. Mimosine serine hydroxymethyltransferase 1 Homo sapiens
3 MCF-7 cells exposed to mimosine for 24 h have a 95% reduction in cSHMT protein, and cSHMT promoter activity is reduced over 95%. Mimosine serine hydroxymethyltransferase 1 Homo sapiens
4 MCF-7 cells exposed to mimosine for 24 h have a 95% reduction in cSHMT protein, and cSHMT promoter activity is reduced over 95%. Mimosine serine hydroxymethyltransferase 1 Homo sapiens
5 Transcription of the cSHMT gene is also inhibited by deferoxamine in MCF-7 cells, indicating that mimosine inhibits cSHMT transcription by chelating iron. Mimosine serine hydroxymethyltransferase 1 Homo sapiens
6 Transcription of the cSHMT gene is also inhibited by deferoxamine in MCF-7 cells, indicating that mimosine inhibits cSHMT transcription by chelating iron. Mimosine serine hydroxymethyltransferase 1 Homo sapiens