Title : Regulation of macrophage interleukin-6 (IL-6) and IL-10 expression by prostaglandin E2: the role of p38 mitogen-activated protein kinase.

Pub. Date : 2000 Mar

PMID : 10762076






6 Functional Relationships(s)
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1 Regulation of macrophage interleukin-6 (IL-6) and IL-10 expression by prostaglandin E2: the role of p38 mitogen-activated protein kinase. Dinoprostone interleukin 6 Mus musculus
2 Regulation of macrophage interleukin-6 (IL-6) and IL-10 expression by prostaglandin E2: the role of p38 mitogen-activated protein kinase. Dinoprostone interleukin 6 Mus musculus
3 We have found that PGE2 can upregulate the levels of both interleukin-10 (IL-10) and IL-6 produced by activated murine macrophages, but the molecular pathways leading to their augmentation differ. Dinoprostone interleukin 6 Mus musculus
4 In contrast, PGE2 can augment IL-6 levels regardless of whether or not p38 kinase is active. Dinoprostone interleukin 6 Mus musculus
5 We found that p38 kinase inhibitors are able to inhibit IL-6 production in activated macrophages, but this occurs primarily as a result of their concurrent inhibition of cyclooxygenase-2 and endogenous PGE2 synthesis. Dinoprostone interleukin 6 Mus musculus
6 These results indicate that macrophage IL-10 and IL-6 expression is differentially regulated by PGE2 and p38 MAP kinase in murine inflammatory macrophages. Dinoprostone interleukin 6 Mus musculus