Pub. Date : 2000 Mar
PMID : 10762076
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Regulation of macrophage interleukin-6 (IL-6) and IL-10 expression by prostaglandin E2: the role of p38 mitogen-activated protein kinase. | Dinoprostone | interleukin 6 | Mus musculus |
2 | Regulation of macrophage interleukin-6 (IL-6) and IL-10 expression by prostaglandin E2: the role of p38 mitogen-activated protein kinase. | Dinoprostone | interleukin 6 | Mus musculus |
3 | We have found that PGE2 can upregulate the levels of both interleukin-10 (IL-10) and IL-6 produced by activated murine macrophages, but the molecular pathways leading to their augmentation differ. | Dinoprostone | interleukin 6 | Mus musculus |
4 | In contrast, PGE2 can augment IL-6 levels regardless of whether or not p38 kinase is active. | Dinoprostone | interleukin 6 | Mus musculus |
5 | We found that p38 kinase inhibitors are able to inhibit IL-6 production in activated macrophages, but this occurs primarily as a result of their concurrent inhibition of cyclooxygenase-2 and endogenous PGE2 synthesis. | Dinoprostone | interleukin 6 | Mus musculus |
6 | These results indicate that macrophage IL-10 and IL-6 expression is differentially regulated by PGE2 and p38 MAP kinase in murine inflammatory macrophages. | Dinoprostone | interleukin 6 | Mus musculus |