Title : Oxidized phospholipids activate PPARalpha in a phospholipase A2-dependent manner.

Pub. Date : 2000 Apr 7

PMID : 10760508






2 Functional Relationships(s)
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1 Fatty acids and eicosanoids are natural PPARalpha ligands. Fatty Acids peroxisome proliferator activated receptor alpha Homo sapiens
2 Using specific inhibitors, it is shown that oxLDL-mediated PPARalpha activation requires phospholipase A2 activity and that the oxidized fatty acids 9- and 13-HODE activate PPARalpha directly. Fatty Acids peroxisome proliferator activated receptor alpha Homo sapiens