Title : In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6.

Pub. Date : 2000 Apr

PMID : 10759690






1 Functional Relationships(s)
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1 TCL was also a moderate inhibitor of CYP1A2 (Ki = 49 +/- 19 microM) and a weak inhibitor of CYP2C9 (Ki > 75 microM), but its effect on the activities of CYP2E1 (Ki = 584 +/- 48 microM) and CYP3A (> 1000 microM) was marginal. Ticlopidine cytochrome P450 family 2 subfamily C member 9 Homo sapiens