Title : Cholinergic and adrenergic modulation of the Ca2+ response to endothelin-1 in human ciliary muscle cells.

Pub. Date : 2000 Apr

PMID : 10752952






4 Functional Relationships(s)
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1 Norepinephrine pretreatment also decreased ET-1-induced [Ca2+]i (10 microM NE + ET-1; 619 +/- 64 nM) compared with ET-1 alone, and NE"s effect could be reversed by propranolol (beta-adrenergic antagonist) treatment. Norepinephrine endothelin 1 Homo sapiens
2 PURPOSE: To determine the cholinergic (carbachol, CCH) and adrenergic (norepinephrine, NE) modulation of Ca2+ response to endothelin-1 in human ciliary smooth muscle (HCSM) cells. Norepinephrine endothelin 1 Homo sapiens
3 Norepinephrine pretreatment also decreased ET-1-induced [Ca2+]i (10 microM NE + ET-1; 619 +/- 64 nM) compared with ET-1 alone, and NE"s effect could be reversed by propranolol (beta-adrenergic antagonist) treatment. Norepinephrine endothelin 1 Homo sapiens
4 Norepinephrine pretreatment also decreased ET-1-induced [Ca2+]i (10 microM NE + ET-1; 619 +/- 64 nM) compared with ET-1 alone, and NE"s effect could be reversed by propranolol (beta-adrenergic antagonist) treatment. Norepinephrine endothelin 1 Homo sapiens