Title : 2-Chloro-s-triazine herbicides induce aromatase (CYP19) activity in H295R human adrenocortical carcinoma cells: a novel mechanism for estrogenicity?

Pub. Date : 2000 Mar

PMID : 10746939






1 Functional Relationships(s)
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1 In this report we demonstrated that the commonly used 2-chloro-s-triazine herbicides atrazine, simazine, and propazine dose-dependently (0-30 microM) induced aromatase (CYP19) activity to an apparent maximum of about 2.5-fold in H295R cells. Atrazine cytochrome P450 family 19 subfamily A member 1 Homo sapiens