Title : Increased tacrolimus levels in a pediatric renal transplant patient attributed to chronic diarrhea.

Pub. Date : 2000 Feb

PMID : 10731062






1 Functional Relationships(s)
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1 As CYP3A4 enzymes and P-gp are present at differing concentrations throughout the gastrointestinal tract, the bioavailability of tacrolimus may be influenced by changes in gastrointestinal transit time in addition to changes in hepatic metabolism. Tacrolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens