Pub. Date : 2000 Apr
PMID : 10725301
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | N-Methylprotoporphyrin is a more potent inhibitor of recombinant human than of recombinant chicken ferrochelatase. | N-methylprotoporphyrin IX | ferrochelatase | Gallus gallus |
| 2 | The potency of N-methylprotoporphyrin IX (N-methylPP) as a ferrochelatase (FC) inhibitor has been previously studied using crude chick embryo liver FC preparations. | N-methylprotoporphyrin IX | ferrochelatase | Gallus gallus |
| 3 | The potency of N-methylprotoporphyrin IX (N-methylPP) as a ferrochelatase (FC) inhibitor has been previously studied using crude chick embryo liver FC preparations. | N-methylprotoporphyrin IX | ferrochelatase | Gallus gallus |
| 4 | The potency of N-methylprotoporphyrin IX (N-methylPP) as a ferrochelatase (FC) inhibitor has been previously studied using crude chick embryo liver FC preparations. | N-methylprotoporphyrin IX | ferrochelatase | Gallus gallus |
| 5 | The first objective of this study was to compare the potency of N-methylPP as an inhibitor of purified chicken FC and crude chick embryo liver FC. | N-methylprotoporphyrin IX | ferrochelatase | Gallus gallus |
| 6 | The first objective of this study was to compare the potency of N-methylPP as an inhibitor of purified chicken FC and crude chick embryo liver FC. | N-methylprotoporphyrin IX | ferrochelatase | Gallus gallus |
| 7 | The EC(50) values of N-methylPP previously observed in crude chick embryo liver FC was 2.9 x 10(-3) nmol/mg protein, and with purified recombinant chicken FC was 2.07 x 10(-3) nmol/mg protein. | N-methylprotoporphyrin IX | ferrochelatase | Gallus gallus |
| 8 | The second objective of this study was to compare the potency of N-methylPP between purified human and chicken FC. | N-methylprotoporphyrin IX | ferrochelatase | Gallus gallus |
| 9 | The EC(50) value of N-methylPP observed in the purified human FC preparation was 1.7 x 10(-6) nmol/mg protein (chicken FC 2.07 x 10(-3) nmol/mg protein). | N-methylprotoporphyrin IX | ferrochelatase | Gallus gallus |
| 10 | Thus, the potency of N-methylPP was much higher with purified human FC than with purified chicken FC. | N-methylprotoporphyrin IX | ferrochelatase | Gallus gallus |