PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10725301-0 2000 N-Methylprotoporphyrin is a more potent inhibitor of recombinant human than of recombinant chicken ferrochelatase. N-methylprotoporphyrin IX 0-22 ferrochelatase Gallus gallus 99-113 10725301-1 2000 The potency of N-methylprotoporphyrin IX (N-methylPP) as a ferrochelatase (FC) inhibitor has been previously studied using crude chick embryo liver FC preparations. N-methylprotoporphyrin IX 15-40 ferrochelatase Gallus gallus 59-73 10725301-1 2000 The potency of N-methylprotoporphyrin IX (N-methylPP) as a ferrochelatase (FC) inhibitor has been previously studied using crude chick embryo liver FC preparations. N-methylprotoporphyrin IX 15-40 ferrochelatase Gallus gallus 75-77 10725301-1 2000 The potency of N-methylprotoporphyrin IX (N-methylPP) as a ferrochelatase (FC) inhibitor has been previously studied using crude chick embryo liver FC preparations. N-methylprotoporphyrin IX 15-40 ferrochelatase Gallus gallus 148-150 10725301-3 2000 The first objective of this study was to compare the potency of N-methylPP as an inhibitor of purified chicken FC and crude chick embryo liver FC. N-methylprotoporphyrin IX 64-74 ferrochelatase Gallus gallus 111-113 10725301-3 2000 The first objective of this study was to compare the potency of N-methylPP as an inhibitor of purified chicken FC and crude chick embryo liver FC. N-methylprotoporphyrin IX 64-74 ferrochelatase Gallus gallus 143-145 10725301-4 2000 The EC(50) values of N-methylPP previously observed in crude chick embryo liver FC was 2.9 x 10(-3) nmol/mg protein, and with purified recombinant chicken FC was 2.07 x 10(-3) nmol/mg protein. N-methylprotoporphyrin IX 21-31 ferrochelatase Gallus gallus 80-82 10725301-6 2000 The second objective of this study was to compare the potency of N-methylPP between purified human and chicken FC. N-methylprotoporphyrin IX 65-75 ferrochelatase Gallus gallus 111-113 10725301-7 2000 The EC(50) value of N-methylPP observed in the purified human FC preparation was 1.7 x 10(-6) nmol/mg protein (chicken FC 2.07 x 10(-3) nmol/mg protein). N-methylprotoporphyrin IX 20-30 ferrochelatase Gallus gallus 62-64 10725301-8 2000 Thus, the potency of N-methylPP was much higher with purified human FC than with purified chicken FC. N-methylprotoporphyrin IX 21-31 ferrochelatase Gallus gallus 68-70