Title : Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proteins with aspartate vs. glutamate at position 298.

Pub. Date : 2000 Mar 14

PMID : 10717002






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proteins with aspartate vs. glutamate at position 298. Aspartic Acid nitric oxide synthase 3 Homo sapiens
2 An endothelial nitric oxide synthase (eNOS) polymorphism in exon 7 (894 G/T) resulting in glutamate or aspartate, respectively, at position 298 on the protein is correlated with severity of cardiopulmonary diseases. Aspartic Acid nitric oxide synthase 3 Homo sapiens
3 An endothelial nitric oxide synthase (eNOS) polymorphism in exon 7 (894 G/T) resulting in glutamate or aspartate, respectively, at position 298 on the protein is correlated with severity of cardiopulmonary diseases. Aspartic Acid nitric oxide synthase 3 Homo sapiens
4 We now show in transfected cells, primary human endothelial cells, and human hearts, that eNOS with aspartate, but not glutamate, at position 298 is cleaved, resulting in the generation of 100-kDa and 35-kDa products. Aspartic Acid nitric oxide synthase 3 Homo sapiens
5 Thus, eNOS with aspartate but not glutamate at position 298 is cleaved, resulting in the generation of N-terminal 35-kDa and C-terminal 100-kDa fragments. Aspartic Acid nitric oxide synthase 3 Homo sapiens