Title : Amphotericin B inhibits the generation of the scrapie isoform of the prion protein in infected cultures.

Pub. Date : 2000 Apr

PMID : 10708429






2 Functional Relationships(s)
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1 Polyene antibiotics such as amphotericin B have been shown to delay the accumulation of PrP(Sc) and to increase the incubation time of the disease after experimental transmission in laboratory animals. Amphotericin B prion protein Mus musculus
2 We show here for the first time that amphotericin B can inhibit PrP(Sc) generation in scrapie-infected GT1-7 and N2a cells. Amphotericin B prion protein Mus musculus