| Protein Name | prion protein |
|---|---|
| Organism | Mus musculus |
| Gene ID | 19122 |
| Gene Symbol | Prnp |
| UniProt | P04925 (PRIO_MOUSE), Q4FJQ7 (Q4FJQ7_MOUSE), Q3UG89 (Q3UG89_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
396
Total Number of Articles : 536 |
Description |
prion protein |
| Gene Summary |
Enables several functions, including amyloid-beta binding activity; aspartic-type endopeptidase inhibitor activity; and cupric ion binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of protein localization to membrane; and positive regulation of protein phosphorylation. Acts upstream of or within several processes, including negative regulation of apoptotic process; regulation of potassium ion transmembrane transport; and response to oxidative stress. Located in several cellular components, including Golgi apparatus; membrane raft; and terminal bouton. Colocalizes with dendrite. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study Creutzfeldt-Jakob disease; Gerstmann-Straussler-Scheinker syndrome; and fatal familial insomnia. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease; Gerstmann-Straussler-Scheinker syndrome; Huntington's disease-like 1; fatal familial insomnia; and kuru. Orthologous to human PRNP (prion protein). [provided by Alliance of Genome Resources, Apr 2022] |
| synonyms |
|
| Properties | |