Title : Differing effects of copper,zinc superoxide dismutase overexpression on neurotoxicity elicited by nitric oxide, reactive oxygen species, and excitotoxins.

Pub. Date : 2000 Feb

PMID : 10698074






1 Functional Relationships(s)
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1 These observations suggest that SOD1 overexpression can reduce neuronal death under conditions where peroxynitrite formation is a significant factor, but may exacerbate neuronal death under conditions of rapid intracellular superoxide formation or impaired H2O2 disposal. Superoxides superoxide dismutase 1, soluble Mus musculus