Title : Mechanisms underlying the steroidogenic synergy of insulin and luteinizing hormone in porcine granulosa cells: joint amplification of pivotal sterol-regulatory genes encoding the low-density lipoprotein (LDL) receptor, steroidogenic acute regulatory (stAR) protein and cytochrome P450 side-chain cleavage (P450scc) enzyme.

Pub. Date : 2000 Jan 25

PMID : 10687849






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 A maximally effective concentration of insulin (1 microg/ml) synergistically augmented LH"s dose-dependent ampilification of progesterone and cAMP accumulation; viz. Progesterone insulin Homo sapiens
2 Insulin dose-response analysis showed that insulin alone minimally elevated basal, but significantly heightened LH"s stimulation of progesterone and cAMP accumulation at (insulin) concentrations as low as 3-10 ng/ml. Progesterone insulin Homo sapiens
3 Insulin dose-response analysis showed that insulin alone minimally elevated basal, but significantly heightened LH"s stimulation of progesterone and cAMP accumulation at (insulin) concentrations as low as 3-10 ng/ml. Progesterone insulin Homo sapiens