Pub. Date : 2000 Feb 21
PMID : 10677633
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The present study investigated the effect of clonidine on the basal and inducible c-jun and c-fos mRNA expression in the nucleus tractus solitarius (middle, mNTS, and rostral, rNTS) and the rostral ventrolateral medulla (caudal, cRVLM, and rostral, rRVLM). | Clonidine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 2 | Clonidine attenuated the increases in c-fos in the mNTS and cRVLM and c-jun gene expression in the mNTS and rRVLM caused by NP-evoked hypotension and also reduced the basal expression of c-jun mRNA in the mNTS and rRVLM. | Clonidine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 3 | These findings establish a causal link between clonidine inhibition of c-fos expression in brainstem and its hypotensive action, and provide the first evidence that clonidine attenuates the expression of the closely linked c-jun gene in neurons implicated in centrally mediated hypotension. | Clonidine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |