Pub. Date : 2000 Feb 15
PMID : 10662821
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine enhances the biosynthesis and secretion of transthyretin from the choroid plexus in rats: implications for beta-amyloid formation. | Nicotine | transthyretin | Rattus norvegicus |
| 2 | Subsequently, quantitative reverse transcription-PCR analysis confirmed these DD-PCR findings and demonstrated that nicotine increased TTR mRNA levels in these regions in a time- and dose-dependent manner. | Nicotine | transthyretin | Rattus norvegicus |
| 3 | Significantly higher TTR protein concentrations were also detected in the ventricular CSF of nicotine-treated rats. | Nicotine | transthyretin | Rattus norvegicus |
| 4 | Immunohistochemical analysis showed that immunoreactive TTR was 41.5% lower in the choroid plexus of nicotine-treated rats compared with the saline controls. | Nicotine | transthyretin | Rattus norvegicus |
| 5 | On the basis of these data, we speculate that the protective effects of nicotine on the development of AD may be attributable, in part, to the increased biosynthesis and secretion of TTR from the choroid plexus. | Nicotine | transthyretin | Rattus norvegicus |