Title : Vicinal dithiol-binding agent, phenylarsine oxide, inhibits inducible nitric-oxide synthase gene expression at a step of nuclear factor-kappaB DNA binding in hepatocytes.

Pub. Date : 2000 Feb 11

PMID : 10660607






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Vicinal dithiol-binding agent, phenylarsine oxide, inhibits inducible nitric-oxide synthase gene expression at a step of nuclear factor-kappaB DNA binding in hepatocytes. oxophenylarsine nitric oxide synthase 2 Rattus norvegicus
2 In the present study, we found that vicinal dithiol-binding agent, phenylarsine oxide (PAO), inhibited the induction of iNOS protein and mRNA as well as the release of nitrite (nitric oxide metabolite) into the culture medium. oxophenylarsine nitric oxide synthase 2 Rattus norvegicus
3 In the present study, we found that vicinal dithiol-binding agent, phenylarsine oxide (PAO), inhibited the induction of iNOS protein and mRNA as well as the release of nitrite (nitric oxide metabolite) into the culture medium. oxophenylarsine nitric oxide synthase 2 Rattus norvegicus
4 These results indicate that PAO inhibits iNOS gene expression at a step of NF-kappaB binding to DNA by modifying its vicinal dithiol moiety, which may play a crucial role for the iNOS regulation in hepatocytes. oxophenylarsine nitric oxide synthase 2 Rattus norvegicus
5 These results indicate that PAO inhibits iNOS gene expression at a step of NF-kappaB binding to DNA by modifying its vicinal dithiol moiety, which may play a crucial role for the iNOS regulation in hepatocytes. oxophenylarsine nitric oxide synthase 2 Rattus norvegicus