Title : Evaluation of oxidative stress based on lipid hydroperoxide, vitamin C and vitamin E during apoptosis and necrosis caused by thioacetamide in rat liver.

Pub. Date : 2000 Feb 21

PMID : 10657587






2 Functional Relationships(s)
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1 After 12 h of thioacetamide (500 mg/kg body weight) administration to rats, the activity of caspase-3-like protease in the liver increased significantly compared to that in the control group. Thioacetamide caspase 3 Rattus norvegicus
2 These results indicate that thioacetamide causes apoptosis in the liver by activating caspase-3, which is released to plasma by successive necrosis. Thioacetamide caspase 3 Rattus norvegicus