Title : Acidic substitution of the activation loop tyrosines in TrkA supports nerve growth factor-independent cell survival and neuronal differentiation.

Pub. Date : 2000 Jan 20

PMID : 10656690






1 Functional Relationships(s)
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1 Herein, we demonstrate that acidic substitution of the activation loop tyrosines is sufficient to induce allosteric changes required for constitutive TrkA kinase activity as well as phosphorylation of TrkA signaling proteins such as Shc, PLCgamma-1, FRS-2 and erk1/2. Tyrosine phospholipase C gamma 1 Homo sapiens