Title : Polyamine-depletion induces p27Kip1 and enhances dexamethasone-induced G1 arrest and apoptosis in human T lymphoblastic leukemia cells.

Pub. Date : 2000 Feb

PMID : 10654447






2 Functional Relationships(s)
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1 The p27Kip1, level was increased by dexamethasone or and DFMO in line with the kinetics of G1 arrest. Dexamethasone cyclin dependent kinase inhibitor 1B Homo sapiens
2 Therefore, the up-regulation of dexamethasone-induced apoptosis by polyamine-depletion may be associated with additive down-regulation of G1 progression via the p27Kip1-pRb pathtway. Dexamethasone cyclin dependent kinase inhibitor 1B Homo sapiens