Title : The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation.

Pub. Date : 2000 Feb 4

PMID : 10652302






2 Functional Relationships(s)
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1 Recently, we found that two conserved transmembrane (TM) aspartates in PS1 are critical for Abeta production, providing evidence that PS1 either functions as a required diaspartyl cofactor for gamma-secretase or is itself gamma-secretase. Aspartic Acid amyloid beta precursor protein Homo sapiens
2 We conclude that presenilins, and their TM aspartates in particular, are attractive targets for lowering Abeta therapeutically to prevent Alzheimer"s disease. Aspartic Acid amyloid beta precursor protein Homo sapiens