Pub. Date : 2000 Jan 15
PMID : 10637135
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Catechol metabolites of polychlorinated biphenyls inhibit the catechol-O-methyltransferase-mediated metabolism of catechol estrogens. | catechol | catechol-O-methyltransferase | Rattus norvegicus |
| 2 | Methylation by catechol-O-methyltransferase (COMT) is the principal means of catechol estrogen (CE) deactivation in the liver and other tissues. | catechol | catechol-O-methyltransferase | Rattus norvegicus |
| 3 | The present studies were conducted to determine the effects of PCBs and catechol metabolites of PCBs on the COMT-mediated catabolism of 4-OHE(2) and 2-OHE(2) in vitro and in vivo. | catechol | catechol-O-methyltransferase | Rattus norvegicus |
| 4 | In classical enzyme kinetics studies, COMT was demonstrated to have a high affinity for catechol PCBs, with K(m)"s approximately equivalent to those of CEs. | catechol | catechol-O-methyltransferase | Rattus norvegicus |