Title : Microtubule inhibitors elicit differential effects on MAP kinase (JNK, ERK, and p38) signaling pathways in human KB-3 carcinoma cells.

Pub. Date : 2000 Jan 10

PMID : 10623471






2 Functional Relationships(s)
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1 All four agents tested (vinblastine, vincristine, Taxol, and colchicine) caused significant (6- to 13-fold) activation of JNK, concomitant inactivation of ERK, and a reduction in basal p38 MAPK activity. Vinblastine mitogen-activated protein kinase 1 Homo sapiens
2 All four agents tested (vinblastine, vincristine, Taxol, and colchicine) caused significant (6- to 13-fold) activation of JNK, concomitant inactivation of ERK, and a reduction in basal p38 MAPK activity. Vinblastine mitogen-activated protein kinase 1 Homo sapiens