Title : Inhibition of melanin synthesis by cystamine in human melanoma cells.

Pub. Date : 2000 Jan

PMID : 10620110






3 Functional Relationships(s)
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1 In contrast, tyrosinase activity in an amelanotic melanoma cell line (MM96L) was rapidly inhibited without consumption of cystamine/cysteamine, in association with the generation of free thiol in the culture medium, and could be enhanced by the cystine transport inhibitor, glutamate. Sulfhydryl Compounds tyrosinase Homo sapiens
2 In amelanotic cells, tyrosinase has a short half-life and is readily inhibited by cystamine/cysteamine whereas tyrosinase in the more mature melanosomes of the pigmented cell appears to be less accessible to proteolytic and thiol attack. Sulfhydryl Compounds tyrosinase Homo sapiens
3 In amelanotic cells, tyrosinase has a short half-life and is readily inhibited by cystamine/cysteamine whereas tyrosinase in the more mature melanosomes of the pigmented cell appears to be less accessible to proteolytic and thiol attack. Sulfhydryl Compounds tyrosinase Homo sapiens