Pub. Date : 2000 Jan
PMID : 10611146
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of the adrenal 11-beta-hydroxylase inhibitor metyrapone on human hepatic cytochrome P-450 expression: induction of cytochrome P-450 3A4. | Metyrapone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Addition of metyrapone to human hepatocyte cultures resulted in the induction of CYP3A4 expression. | Metyrapone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | The pregnane X receptor (PXR), which has recently been shown to mediate the transcriptional induction of CYP3A4 expression in response to rifampicin, was activated by metyrapone in CV-1 cells transiently cotransfected with an expression vector encoding the human PXR and a reporter construct containing the everted repeat sequence that confers CYP3A4 induction responsiveness to inducers within its promoter. | Metyrapone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | The pregnane X receptor (PXR), which has recently been shown to mediate the transcriptional induction of CYP3A4 expression in response to rifampicin, was activated by metyrapone in CV-1 cells transiently cotransfected with an expression vector encoding the human PXR and a reporter construct containing the everted repeat sequence that confers CYP3A4 induction responsiveness to inducers within its promoter. | Metyrapone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | Metyrapone activated the human PXR at concentrations that also resulted in the induction of CYP3A4 in human cultured hepatocytes. | Metyrapone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 6 | Metyrapone treatment is therefore unlikely to result in the induction of CYP1A1 but may induce the expression of CYP3A4 in humans. | Metyrapone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |