Title : Antileukemic activity and mechanism of action of cordycepin against terminal deoxynucleotidyl transferase-positive (TdT+) leukemic cells.

Pub. Date : 2000 Feb 1

PMID : 10609556






2 Functional Relationships(s)
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1 The nucleoside analogue cordycepin (3"-deoxyadenosine, 3"-dA) is substantially more cytotoxic to terminal deoxynucleotidyl transferase positive (TdT+) leukemic cells than to TdT leukemic cells in vitro in the presence of an adenosine deaminase inhibitor, deoxycoformycin (dCF), and has been considered as a therapeutic agent for TdT+ leukemia. Nucleosides DNA nucleotidylexotransferase Homo sapiens
2 The nucleoside analogue cordycepin (3"-deoxyadenosine, 3"-dA) is substantially more cytotoxic to terminal deoxynucleotidyl transferase positive (TdT+) leukemic cells than to TdT leukemic cells in vitro in the presence of an adenosine deaminase inhibitor, deoxycoformycin (dCF), and has been considered as a therapeutic agent for TdT+ leukemia. Nucleosides DNA nucleotidylexotransferase Homo sapiens