| Protein Name | DNA nucleotidylexotransferase |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 1791 |
| Gene Symbol | DNTT |
| UniProt | P04053 (TDT_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
534
Total Number of Articles : 1305 |
Description |
DNA nucleotidylexotransferase |
| Gene Summary |
This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008] |
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