Title : Transcriptional activation of the human manganese superoxide dismutase gene mediated by tetradecanoylphorbol acetate.

Pub. Date : 1999 Dec 24

PMID : 10601319






7 Functional Relationships(s)
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1 Transcriptional activation of the human manganese superoxide dismutase gene mediated by tetradecanoylphorbol acetate. Tetradecanoylphorbol Acetate superoxide dismutase 2 Homo sapiens
2 Transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA induced by a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), was examined to identify the responsive transcriptional regulator. Tetradecanoylphorbol Acetate superoxide dismutase 2 Homo sapiens
3 Transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA induced by a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), was examined to identify the responsive transcriptional regulator. Tetradecanoylphorbol Acetate superoxide dismutase 2 Homo sapiens
4 Transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA induced by a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), was examined to identify the responsive transcriptional regulator. Tetradecanoylphorbol Acetate superoxide dismutase 2 Homo sapiens
5 Transcriptional activation of human manganese superoxide dismutase (MnSOD) mRNA induced by a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), was examined to identify the responsive transcriptional regulator. Tetradecanoylphorbol Acetate superoxide dismutase 2 Homo sapiens
6 The region between -1292 and -1202 contains a cAMP-responsive element-like sequence, TGACGTCT, which we identified as the manganese superoxide dismutase TPA-responsive element, MSTRE. Tetradecanoylphorbol Acetate superoxide dismutase 2 Homo sapiens
7 These results led us to conclude that the human MnSOD gene having the promoter construct used in this study is induced by TPA via activation of a CREB-1/ATF-1-like factor and not via either NF-kappaB or AP-1. Tetradecanoylphorbol Acetate superoxide dismutase 2 Homo sapiens