Pub. Date : 1999 Nov
PMID : 10598880
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of cellular responses to interleukin 6 is blocked by staurosporine. | Staurosporine | interleukin 6 | Homo sapiens |
| 2 | The effects of the microbial alkaloid staurosporine (SS) on IL-6 signaling through gp130, and also on the internalization of the IL-6 receptor complex, were studied using HepG2 cells which are well-characterized in their ability to respond to IL-6 by upregulating acute-phase protein production. | Staurosporine | interleukin 6 | Homo sapiens |
| 3 | SS was found effective in the blockade of the signaling cascade of IL-6: phosphorylation of both gp130 and Stat3 was eliminated by SS treatment and the production of IL-6 stimulated haptoglobin by the cells was abolished. | Staurosporine | interleukin 6 | Homo sapiens |
| 4 | SS was found effective in the blockade of the signaling cascade of IL-6: phosphorylation of both gp130 and Stat3 was eliminated by SS treatment and the production of IL-6 stimulated haptoglobin by the cells was abolished. | Staurosporine | interleukin 6 | Homo sapiens |
| 5 | The ability of SS to void the capacity of IL-6, and IL-6-related cytokines such as Oncostatin M, to deliver growth and differentiation signals may be one process by which this agent could promote apoptosis in a variety of cell types. | Staurosporine | interleukin 6 | Homo sapiens |
| 6 | The ability of SS to void the capacity of IL-6, and IL-6-related cytokines such as Oncostatin M, to deliver growth and differentiation signals may be one process by which this agent could promote apoptosis in a variety of cell types. | Staurosporine | interleukin 6 | Homo sapiens |