Pub. Date : 1999 Nov 15
PMID : 10597900
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of CYP1A1 enzyme activity in mouse hepatoma cell culture by soybean isoflavones. | Isoflavones | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 2 | We found that the isoflavones genistin and daidzin, and their respective aglucone forms daidzein and genistein, block 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dioxin)-induced CYP1A1 enzyme activity. | Isoflavones | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 3 | This inhibition is correlated with the capacity of the isoflavones to prevent CYP1A1-mediated covalent binding of benzo[a]pyrene (BaP) metabolites to DNA. | Isoflavones | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 4 | We therefore evaluated the isoflavones for direct effects on the CYP1A1 enzyme. | Isoflavones | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 5 | The extent of CYP1A1 inhibition increases with time of preincubation at 37 degrees C, but not at 4 degrees C, in the presence of isoflavone plus NADPH; after 60 min preincubation the inhibition remains non-competitive, with apparent Ki values of 55 microM and 50 microM, respectively. | Isoflavones | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 6 | The dependency on NADPH, temperature and time for inhibition of CYP1A1 suggests that metabolism of either isoflavone or molecular oxygen to reactive species is required. | Isoflavones | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 7 | Isoflavone-mediated inhibition of CYP1A1 activity may contribute to the mechanism by which these soybean isoflavones protect against carcinogenesis. | Isoflavones | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 8 | Isoflavone-mediated inhibition of CYP1A1 activity may contribute to the mechanism by which these soybean isoflavones protect against carcinogenesis. | Isoflavones | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |