Pub. Date : 1999 Sep 9
PMID : 10575059
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The lipophilic drugs lovastatin, simvastatin, atorvastatin, cerivastatin and fluvastatin are metabolized via the cytochrome P450 (CYP450) system in the liver and the gut, making them subject to potential interactions with concomitantly administered drugs that are competing for metabolism via this system. | Lovastatin | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 2 | The lipophilic drugs lovastatin, simvastatin, atorvastatin, cerivastatin and fluvastatin are metabolized via the cytochrome P450 (CYP450) system in the liver and the gut, making them subject to potential interactions with concomitantly administered drugs that are competing for metabolism via this system. | Lovastatin | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 3 | Clinically important interactions with simvastatin or lovastatin and drugs that inhibit the 3A4 isoenzyme (part of the CYP450 system) may result in myopathy and rhabdomyolysis, which can be fatal. | Lovastatin | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |