Title : Oxidized low density lipoprotein inhibits inducible nitric oxide synthase, GTP cyclohydrolase I and transforming growth factor beta gene expression in rat macrophages.

Pub. Date : 1999 Sep

PMID : 10574472






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 NO generation by inducible nitric oxide synthase (iNOS) is dependent on the presence of cofactors for NO generation, tetrathydrobiopterin (BH4) among them. sapropterin nitric oxide synthase 2 Rattus norvegicus
2 NO generation by inducible nitric oxide synthase (iNOS) is dependent on the presence of cofactors for NO generation, tetrathydrobiopterin (BH4) among them. sapropterin nitric oxide synthase 2 Rattus norvegicus
3 Therefore, the aim of our recent study was to investigate the influence of ox-LDL on the expression of iNOS and GTP cyclohydrolase I (GTP-CH I), the key enzyme involved in the BH4 synthesis as well as the ox-LDL effect on TGF-beta expression in rat macrophages stimulated with IFNgamma (250 U/ml) and LPS (500 ng/ml). sapropterin nitric oxide synthase 2 Rattus norvegicus